by Tyndall in that eloquent passage in the Belfast address, where he declared himself driven by an intellectual necessity to cross the boundary line of the experimental evidence and to discern in non-living matter, as he said, the promise and potency of every form and quality of terrestrial life. This intellectual necessity was created by a conviction of the continuity and consistency of natural phenomena, which is almost inseparable from the scientific attitude towards nature. But Tyndall's words stood after all for a confession of faith, not for a statement of fact; and they soared far above the terra firma of the actual evidence. At the present day we too may find ourselves logically driven to the view that living things first arose as a product of non-living matter. We must fully recognize the extraordinary progress that has been made by the chemist in the artificial synthesis of compounds formerly known only as the direct products of living protoplasm. But it must also be admitted that we are still wholly without evidence of the origin of any living thing, at any period of the earth's history, save from some other living thing; and after more than two centuries Redi's aphorism omne vivum e vivo retains to-day its full force. It is my impression therefore that the time has not yet come when hypotheses regarding a different origin of life can be considered as practically useful.
If I have the temerity to ask your attention to the fundamental problem towards which all lines of biological inquiry sooner or later lead us it is not with the delusion that I can contribute anything new to the prolonged discussions and controversies to which it has given rise. I desire only to indicate in what way it affects the practical efforts of biologists to gain a better understanding of the living organism, whether regarded as a group of existing phenomena or as a product of the evolutionary process; and I shall speak of it, not in any abstract or speculative way, but from the standpoint of the working naturalist. The problem of which I speak is that of organic mechanism and its relation to that of organic adaptation. How in general are the phenomena of life related to those of the non-living world? How far can we profitably employ the hypothesis that the living body is essentially an automaton or machine, a configuration of material particles, which, like an engine or a piece of clockwork, owes its mode of operation to its physical and chemical construction? It is not open to doubt that the living body is a machine. It is a complex chemical engine that applies the energy of the food-stuffs to the performance of the work of life. But is it something more than a machine? If we may imagine the physico-chemical analysis of the body to be carried through to the very end, may we expect to find at last an unknown something that transcends such analysis and is neither a form of physical energy nor anything given in the physical or chemical configuration of the body? Shall we find anything corresponding to the usual popular conception--which was also along the view of physiologists--that the body is "animated" by a specific "vital principle," or "vital force," a dominating "arch?us" that exists only in the realm of organic nature? If such a principle exists, then the mechanistic hypothesis fails and the fundamental problem of biology becomes a problem sui generis.
In its bearing on man's place in nature this question is one of the most momentous with which natural science has to deal, and it has occupied the attention of thinking men in every age. I cannot trace its history, but it will be worth our while to place side by side the words of three of the great leaders of modern scientific and philosophic thought. The saying has been attributed to Descartes, "Give me matter and I will construct the world"--meaning by this the living world as well as the non-living; but Descartes specifically excepted the human mind. I do not know whether the great French philosopher actually used these particular words, but they express the essence of the mechanistic hypothesis that he adopted. Kant utterly repudiated such a conception in the following well known passage: "It is quite certain that we cannot become adequately acquainted with organized creatures and their hidden potentialities by means of the merely mechanical principles of nature, much less can we explain them; and this is so certain that we may boldly assert that it is absurd for man even to make such an attempt or to hope that a Newton may one day arise who will make the production of a blade of grass comprehensible to us according to natural laws that have not been ordered by
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